Sex x Stress
A Single Cell Dataset of Male and Female PVN
This dataset contains cells from the PVN of male and female mice 5 hours after 15min acute restraint stress (ARS) or 21 days of chronic mild stress and 15min of acute restraint stress (CMS ARS), and naive controls.
(A) Experimental Design of the Dataset. (B) Region isolated.
Find us on our website.
Download the data on GEO: GSE201032.
Find the original code on GitHub.
Cell information vs gene expression on reduced dimensions
In this tab, users can visualise both cell information and gene expression side-by-side on low-dimensional representions.Dimension Reduction
Cell information vs cell information on dimension reduction
In this tab, users can visualise two cell informations side-by-side on low-dimensional representions.Dimension Reduction
Gene expression vs gene expression on dimension reduction
In this tab, users can visualise two gene expressions side-by-side on low-dimensional representions.Dimension Reduction
Coexpression of two genes on reduced dimensions
In this tab, users can visualise the coexpression of two genes on low-dimensional representions.Dimension Reduction
Cell information / gene expression violin plot / box plot
In this tab, users can visualise the gene expression or continuous cell information (e.g. Number of UMIs / module score) across groups of cells (e.g. libary / clusters).Proportion / cell numbers across different cell information
In this tab, users can visualise the composition of single cells based on one discrete cell information across another discrete cell information. Usage examples include the library or cellcycle composition across clusters.Gene expression bubbleplot / heatmap
In this tab, users can visualise the gene expression patterns of multiple genes grouped by categorical cell information (e.g. library / cluster).The normalised expression are averaged, log-transformed and then plotted.
Reference: Brivio E., Kos A., Ulivi AF., Karamihalev S., Ressle A., Stoffel R., Hirsch D., Stelzer G., Schmidt MV., Lopez JP., Chen A. Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus , Cell Reports (2023) doi: 10.1016/j.celrep.2023.112874
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